Cov ntsiav tshuaj coated yog cov ntaub ntawv ntawm qhov ncauj ntau npaum li cas uas ib lossis ntau cov khoom siv txheej txheej tau siv rau saum npoo ntawm cov tshuaj tseem ceeb (cov ntsiav tshuaj dawb) siv cov txheej txheem tshwj xeeb. Lawv lub hom phiaj tseem ceeb yog txhawm rau txhim kho qhov tsos, kev ruaj ntseg, tso tawm cov yam ntxwv, lossis cov neeg mob ua raws li cov tshuaj, thaum tiv thaiv nws los ntawm ib puag ncig ib puag ncig xws li av noo, lub teeb, lossis oxygen. Txheej txheej tshuab yog ib feem tseem ceeb ntawm kev lag luam kws tshuaj niaj hnub no thiab tau siv dav hauv cov ntsiav tshuaj zoo tib yam, txhawb nqa - cov qauv tsim tawm, thiab cov phiaj xwm xa tshuaj.
Los ntawm kev txhais, cov qauv tseem ceeb ntawm cov ntsiav tshuaj coated muaj ob ntu: ib txheej sab hauv ntawm cov ntsiav tshuaj dawb, tsim los ntawm kev sib xyaw cov khoom siv tshuaj nquag nrog cov khoom siv ntxiv thiab nias nws ua ke, thiab txheej txheej txheej txheej. Cov ntaub ntawv txheej feem ntau suav nrog cov suab thaj (xws li sucrose), polymers (xws li hydroxypropyl methylcellulose thiab ethyl cellulose), pigments, plasticizers, thiab lubricants. Raws li lawv txoj haujlwm, cov ntsiav tshuaj coated tuaj yeem raug cais raws li hauv qab no:
1. Qab Zib-cov ntsiav tshuaj coated: Cov txheej txheem txheej txheem ib txwm siv, siv sucrose ua cov khoom tseem ceeb, muab lub ntsej muag du thiab npog qhov tsis hnov tsw ntawm cov tshuaj, tab sis cov txheej txheem tsim khoom yog qhov nyuaj thiab tsis muaj dej tsis zoo.
2. Zaj duab xis-cov ntsiav tshuaj coated: Cov no siv cov txheej nyias nyias ntawm polymer txheej, muab qhov zoo xws li lub teeb yuag, kev ua haujlwm siab ntau lawm, thiab tsis muaj dej noo. Tam sim no lawv yog cov txheej txheem tseem ceeb.
3. Enteric-cov ntsiav tshuaj coated: Cov khoom txheej txheej tsuas yog yaj nyob rau hauv cov pH tshwj xeeb hauv cov hnyuv (xws li cellulose acetate phthalate), tiv thaiv cov tshuaj los ntawm plab acid degradation los yog txo kev ua xua rau lub plab mucosa.
4. Sustained - tso tawm / tswj tau - tso tawm cov ntsiav tshuaj coated: Los ntawm ntau- txheej txheej lossis cov txheej txheem polymer tshwj xeeb, qhov tso tawm ntawm cov tshuaj hauv lub cev yog tswj tau, ua kom lub sijhawm ua haujlwm ntev.
Tus nqi tseem ceeb ntawm cov ntsiav tshuaj coated yog nyob rau hauv lawv versatility. Piv txwv li, zaj duab xis txheej ho txhim kho cov tshuaj stability ntawm cov tshuaj thiab ncua lub neej txee; enteric txheej tiv thaiv kev mob plab (xws li mob plab hnyuv los ntawm cov tshuaj aspirin); sustained- tso tawm txheej txo cov koob tshuaj ntau zaus los ntawm kev kho qhov kev tso tawm nkhaus, txhim kho tus neeg mob ua raws. Tsis tas li ntawd, txheej txheej txhim kho cov tsos thiab kev txheeb xyuas cov ntsiav tshuaj, ua kom yooj yim rau kev sib txawv ntawm cov tshuaj sib txawv lossis ntau npaum li cas.
Hauv kev lag luam kws tshuaj, qhov tseeb ntawm txheej txheej txheej txheem ncaj qha cuam tshuam rau cov tshuaj zoo. Cov txheej txheem niaj hnub txheej txheej (xws li fluidized txaj txheej thiab yias txheej) ua ke nrog kev tswj xyuas kom paub meej tias txheej txheej thiab batch-rau-batch sib xws. Nrog rau kev txhim kho cov ntaub ntawv txheej tshiab (xws li biodegradable polymers), daim ntawv thov ntawm cov ntsiav tshuaj coated hauv cov tshuaj precision thiab tus kheej xa tshuaj yuav raug nthuav dav ntxiv. Nyob rau hauv luv luv, coated ntsiav tshuaj tsis yog tsuas yog ib tug innovation nyob rau hauv cov tshuaj formulation, tab sis kuj yog ib tug tseem ceeb technological cab kuj rau kev txhim kho kev ua tau zoo thiab kev nyab xeeb.
